N Mackman Selected Research

Thromboplastin (Tissue Factor)

1/2019	mTOR kinase inhibition reduces tissue factor expression and growth of pancreatic neuroendocrine tumors.
1/2018	Androgen receptor dampens tissue factor expression via nuclear factor-κB and early growth response protein 1.
11/2017	Human pancreatic tumors grown in mice release tissue factor-positive microvesicles that increase venous clot size.
1/2017	Myeloid but not epithelial tissue factor exerts protective anti-inflammatory effects in acid aspiration-induced acute lung injury.
4/2016	OC-04 - Tissue factor positive microvesicles activate platelets in vitro and in vivo and enhance thrombosis in mice.
1/2016	Tissue factor deficiency increases alveolar hemorrhage and death in influenza A virus-infected mice.
1/2016	Tissue factor-positive tumor microvesicles activate platelets and enhance thrombosis in mice.
1/2016	Is leukocyte tissue factor the key to venous thrombosis in antiphospholipid syndrome?
8/2015	Venous thrombosis and cancer: from mouse models to clinical trials.
5/2015	Procoagulant microparticles in dogs with immune-mediated hemolytic anemia.

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N Mackman Research Topics

Disease

14	Thrombosis (Thrombus) 01/2018 - 03/2000
13	Neoplasms (Cancer) 01/2019 - 03/2000
8	Inflammation (Inflammations) 01/2017 - 12/2000
5	Venous Thromboembolism 01/2021 - 11/2008
5	Hemorrhage 01/2018 - 02/2001
4	Pancreatic Neoplasms (Pancreatic Cancer) 01/2021 - 11/2008
4	Neoplasm Metastasis (Metastasis) 01/2014 - 06/2000
3	Antiphospholipid Syndrome (Antiphospholipid Antibody Syndrome) 02/2016 - 04/2010
3	Sepsis (Septicemia) 04/2011 - 03/2000
3	Fibrosis (Cirrhosis) 10/2010 - 11/2002
2	Infections 01/2016 - 07/2006
2	Venous Thrombosis (Deep-Vein Thrombosis) 01/2016 - 04/2010
2	Brain Neoplasms (Brain Tumor) 07/2012 - 02/2010
2	Endotoxemia 07/2009 - 07/2009
2	Reperfusion Injury 03/2005 - 12/2000
2	Hypoxia (Hypoxemia) 06/2000 - 04/2000
1	Primitive Neuroectodermal Tumors (PNET) 01/2019
1	Adenocarcinoma 01/2019
1	Neuroendocrine Tumors (Neuroendocrine Tumor) 01/2019
1	Ischemic Stroke 01/2018
1	Atrial Fibrillation 01/2018
1	Prostatic Neoplasms (Prostate Cancer) 01/2018
1	Atherosclerosis 01/2018
1	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 01/2018
1	Acute Lung Injury 01/2017
1	Factor XI Deficiency (Hemophilia C) 01/2017
1	Edema (Dropsy) 01/2017
1	Pathologic Constriction (Stenosis) 04/2016
1	Carotid Artery Injuries 02/2016
1	Lung Neoplasms (Lung Cancer) 08/2015
1	Ovarian Neoplasms (Ovarian Cancer) 08/2015
1	Wounds and Injuries (Trauma) 03/2015
1	Myocardial Infarction 01/2015
1	Myocarditis (Carditis) 01/2015
1	Diabetic Nephropathies (Diabetic Nephropathy) 10/2010
1	Glioma (Gliomas) 02/2010
1	Disseminated Intravascular Coagulation 07/2009
1	Pregnancy Complications 10/2008
1	Hemosiderosis 08/2007

Drug/Important Bio-Agent (IBA)

26	Thromboplastin (Tissue Factor)IBA 01/2019 - 03/2000
8	Thrombin FDA Link 01/2021 - 12/2000
7	FibrinIBA 01/2018 - 04/2000
7	Hemostatics (Antihemorrhagics)IBA 01/2017 - 11/2001
4	AnticoagulantsIBA 01/2018 - 03/2005
4	Biomarkers (Surrogate Marker)IBA 01/2018 - 07/2009
3	Peptide Hydrolases (Proteases)FDA Link 01/2018 - 07/2009
3	Antiphospholipid AntibodiesIBA 02/2016 - 10/2008
2	Phosphotransferases (Kinase)IBA 01/2019 - 08/2012
2	Proteinase-Activated ReceptorsIBA 01/2018 - 07/2009
2	Low-Molecular-Weight Heparin (Heparin, Low Molecular Weight)IBA 01/2018 - 08/2015
2	ReninIBA 01/2018 - 07/2000
2	Interleukin-6 (Interleukin 6)IBA 01/2017 - 08/2015
2	Platelet Aggregation Inhibitors (Antiplatelet Drugs)IBA 04/2016 - 01/2016
2	Clopidogrel (Plavix)FDA Link 04/2016 - 01/2016
2	ferric chlorideIBA 02/2016 - 09/2011
2	Messenger RNA (mRNA)IBA 04/2011 - 05/2000
2	Monoclonal AntibodiesIBA 10/2008 - 12/2000
2	HemosiderinIBA 08/2007 - 11/2002
2	Oxygen (Dioxygen)IBA 06/2000 - 04/2000
1	Tumor Biomarkers (Tumor Markers)IBA 01/2021
1	CA-19-9 Antigen (CA 19-9 Antigen)IBA 01/2021
1	CarbohydratesIBA 01/2021
1	Adenosine Triphosphate (ATP)IBA 01/2019
1	Mechanistic Target of Rapamycin Complex 1IBA 01/2019
1	Proteins (Proteins, Gene)FDA Link 01/2019
1	Protein Isoforms (Isoforms)IBA 01/2019
1	sapanisertibIBA 01/2019
1	estropipate (Ogen)FDA LinkGeneric 01/2018
1	AndrogensIBA 01/2018
1	AngiotensinsIBA 01/2018
1	Protein CIBA 01/2018
1	Testosterone (Sustanon)FDA Link 01/2018
1	Plasminogen Activator Inhibitor 1IBA 01/2018
1	Enoxaparin (Lovenox)FDA LinkGeneric 01/2018
1	Carboxypeptidase B2 (Thrombin Activatable Fibrinolysis Inhibitor)IBA 01/2018
1	AcidsIBA 01/2017
1	Factor XI (Plasma Thromboplastin Antecedent)IBA 01/2017
1	Antithrombin IIIIBA 04/2016
1	Toll-Like Receptor 4IBA 02/2016
1	AntibodiesIBA 02/2016
1	Cell-Free Nucleic AcidsIBA 08/2015
1	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 08/2015
1	Thrombopoietin (c-mpl Ligand)IBA 08/2015
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 08/2015
1	PhosphatidylserinesIBA 05/2015
1	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 01/2015
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2015
1	Thrombin Receptors (Thrombin Receptor)IBA 01/2014
1	ThrombomodulinIBA 01/2014
1	Endothelial Protein C ReceptorIBA 01/2014
1	Platelet Membrane GlycoproteinsIBA 01/2014
1	MAP Kinase Kinase Kinases (MAP Kinase Kinase Kinase)IBA 08/2012
1	Small Interfering RNA (siRNA)IBA 08/2012
1	ErbB Receptors (EGF Receptor)IBA 08/2012
1	fibrin fragment D (D-dimer)IBA 07/2012
1	AlbuminsIBA 10/2010
1	Bevacizumab (Avastin)FDA Link 02/2010
1	Isoproterenol (Isoprenaline)FDA LinkGeneric 08/2007

Therapy/Procedure

5	Therapeutics 01/2018 - 02/2010
1	Laser Therapy (Surgery, Laser) 03/2015